a16z Podcast Transcripts

The New AI Agents That Shop, Plan, and Gossip

Andrew Huberman’s Three Rules for Better Health and Focus

The Robots Already Working in American Factories | Tutor Intelligence

How Bending Spoons Built a $20 Billion Compounder | Luca Ferrari

Can AI Fix Professional Networking? | Inside Cosign

Why AI Could Turn Small Law Firms Into Billion-Dollar Businesses

The Startups Rebuilding American Industry | The AD50

Mark Cuban’s Plan to Make Healthcare Affordable

Reinventing School for the AI Era | Joe Liemandt, Gagan Biyani & Erik Torenberg

OpenAI: When AI Agents Use Computers Faster Than You

The New Startup Playbook | Box CEO Aaron Levie

What It Takes to Win as a Founder | Ben Horowitz

Amazon CEO Andy Jassy on Why Amazon Is Investing $220 Billion in AI

The Frontier Ideas a16z Wants to Fund | Marc Andreessen, Ben Horowitz & Chris Dixon

The Missing Infrastructure for AI Agents: Documents | Reducto’s Adit Abraham

What Happens When Everyone Has a Health Expert in Their Pocket? | OpenAI’s Karan Singhal

What Happens When Al Agents Can Spend Your Money?

Why Real-World AI Is Harder Than the Benchmark | EliseAI’s Mario Martone

Why AI Could Finally Fix Healthcare Access | Zocdoc CEO Oliver Kharraz

AI Can Write the Code. Can It Run the System? | Grepr CEO Jad Naous

When AI Agents Start Spending Your Money | Alex Rampell & Terry Angelos

Can Open Models Keep Up With the AI Frontier? | Nathan Lambert

Can AI Break Cryptography? What the Experts Actually Think

The Race to Recursive Self-Improving AI

Nick Bostrom: How Should We Navigate Superintelligence?

What Makes a Great Entrepreneur? | Ben Horowitz on Vintage x Vintage

Chips, Memory, and Power | Pat Gelsinger

Building the Cloud for an Agentic World | AWS CEO Matt Garman

How Valon Rebuilt a $13 Trillion Industry From Scratch

Building Defense for the Agentic Era: Kevin Mandia

The Top 100 Consumer AI Apps: Who’s Actually Paying?

David George & Jack Altman on AI, Autonomy, and the Next $25 Trillion

Beyond the God Model | Alex Atallah & Amjad Masad

Why AI Agents Can Beat the Incumbents

Rebuilding the Internet for Privacy | Barrett Lyon on DoxxNet

The $1 Trillion AI Buildout | State of Markets

The Personal Agent Race Is Here | Anish Acharya & David Pawlan

AI Can Write Code. Why Isn’t Software Better?

Building a Team at AI Speed | Harvey’s Maggie Landers

Aaron Levie, Steven Sinofsky & Martin Casado: How Do You Secure a World of AI Agents?

The Reputation Graph of Silicon Valley | Introducing Cosign

The Case Against an AI Pause | Eddy Lazzarin

Amjad Masad on Rethinking College for the AI Era

Why a16z is Building a New School for the AI Era | Ben Horowitz

AI Safety Language Is Destroying the Debate | Steven Sinofsky

Nas, Grandmaster Caz, Steve Stoute & Ben Horowitz on Paying Hip-Hop’s Pioneers Their Due

What Makes a Consumer AI Product Stick? | Josh Elman

Databricks CEO on AI Pacing, Cyber Risk, and the Enterprise

The Next Frontier of AI Video Is Control

The AI-Native CRM

The Age of Body Futurism | Ruby Justice Thelot

Greg Brockman on Why OpenAI Says We’re Entering the AGI Era

World Models, Robotics, and the Future of 3D AI

Why Companies Are Becoming a Series of Loops | Anish Acharya on Lenny’s Podcast

What It Takes to Build a Startup | Andrew Chen & Matt Perault

How AI Is Rewriting the Power Law of Venture Capital

Who Grades the AI Models? | Ben Horowitz & Rayan Krishnan

OpenAI Researchers on the Future of Mathematical Reasoning

Can Open Source Keep AI Power From Concentrating?

Your AI Doctor Is Coming | Julie Yoo

Aaron Levie on Why Open AI Wins

Fei Fei Li: The Race to Build World Models For AI

The $100B Niches Hiding Inside Payments

Inside Moderna’s Personalized Cancer Vaccine

Daniel Litt: The Mathematician's Guide to AI

Gavin Baker: Why AI Demand Is Outrunning Compute Supply

Why a16z Launched the Machine Age Fund | Jen Kha

Why 1,200 AI Agents Started Working Together | Ryan Greenblatt

The Infrastructure Behind the Machine Age

Inside Cursor: The Anatomy of a Generational Startup

The State of AI: Macro, Apps, and Consumer

The New Economics of AI | Martin Casado & Steven Sinofsky

Why Medical AI Needs a Referee | Protege's Engy Ziedan

Martin Casado on Where the Value Is Going in AI

How Microsoft Is Securing the Agentic Enterprise | Aaron Zollman

How Global Networks Are Reshaping Startup Success

How Whatnot Built a Global Marketplace

How Do You Defend Against AI That Can Hack?

Stripe’s AI Strategy: Build More, Not Less

Ben Horowitz and Travis Kalanick on Building Again

The Two Ways to Sell AI: Lighthouse or Landgrab?

Garry Tan on Taste, Agents and Founder Ambition

The CISO Playbook for AI Agents | Datadog

The Self-Improving Company | Kavak's AI Playbook

The Reality of AI-Powered Cyberattacks | Truffle Security & Socket

How Open-Source AI Became Critical Infrastructure

Three Startups Reinventing Critical Infrastructure

OpenAI's Joshua Achiam: Did We Already Reach AGI?

Ruby Thelot on Internet Culture, AI, and the Future of Taste

Marc Andreessen and Chris Dixon: What’s at Stake in Crypto Regulation

Decagon’s Playbook for Building Enterprise AI Applications

AI for America's Small Businesses | Lassie

AI Micro Dramas, Generative Media, and the Future of Creativity

Fei-Fei Li on Spatial Intelligence and Robotics

Steven Sinofsky: AI Doesn't Need New Rules Yet

Ben Horowitz: The Fight Over Open Source AI

Sriram Krishnan on Open Source AI's Biggest Week Yet

Building the Physical AI Stack | Travis Kalanick on TBPN

Travis Kalanick Is Back | Building the Future of Industrial AI

Why Physical AI Is the Next Frontier | Applied Intuition

Hugging Face's CEO on Open Source AI, Model Routing, and the Future of Competition

Amjad Masad on Going Direct, Building Replit, and the Future of Software

Replay 2025: David Sacks on AI, Crypto, and America's Technology Future

Can Anyone Catch NVIDIA? | The Future of Chips and Infrastructure

Is AI a Bubble? | Gavin Baker on Data Centers, GPUs, and the AI Economy

Before Blockchains, There Was State Machine Replication

How Bitcoin Rewired a Classic Computer Science Problem

Mark Zuckerberg & Priscilla Chan: How AI Will Help Cure Disease

Adam Neumann: This Is How You Build Iconic Companies

Is Software Losing Its Head?

Don’t Follow Your Passion | Ben Horowitz’s Advice for New Graduates

Technology, Alliances, and American Leadership.

Outsmarting Uber: Why Bolt Wins in Europe

Rick Rubin on AI, Creativity, and The Way of Code

Building AI for Creators | Luma & Phota Labs

Beyond P(doom): Marc Andreessen - Betting on America

AI Is Crossing the Frontier of Human Knowledge | Kevin Weil

Marc Andreessen on AI, Technology, and the Future of Humanity

What Happens to Design After AI?

What’s Next for Consumer AI? | Josh Elman Joins a16z

Jake Paul & Anti Fund: From Creator to Investor

The New Rules of Media | Marc Andreessen & Ben Horowitz

The Fintech Playbook for Latin America

Jack Altman on Product-Market Fit

AI, Design, and the Power of Open Models

Samo Burja on Growth, Energy, and AI

Designing the Physical World with AI

Tyler Cowen & Alex Tabarrok on AI, Jobs, and Economic Growth

Building Search for AI Agents with Exa CEO Will Bryk

AI Agents and the Fight for Customer Data

AI Eats the World? A Reality Check with Benedict Evans

Balaji and Steven Glinert on Network States, Supply Chains, and Allied Coalition Strategy

Steven Sinofsky on Apple at 50, Microsoft, and the Future of Computing

Building AI Agents for Enterprise Operations

Why $1B Exits are Dead

Stablecoins, AI Agents, and The Future of Global Banking

Marc Rowan on Private Markets, Software Repricing, and Capital Allocation

Robin Hanson on Prediction Markets, Gambling, and the Future of Forecasting

Why AI Isn’t Killing SaaS Yet

Hugging Face's Clem Delangue on Open Source AI and the LLM Bubble | MTS Live

How Superhuman Took Over Silicon Valley Email

Marc Andreessen on AI, California, and the Future of America | Joe Rogan

Rebuilding The American Shipyard

The Plan to Make American Crime Obsolete

Vitalik Buterin on Human Agency in the AI Era

Ben Horowitz - "Your ONLY job is Right Product, Right Time"

Energy, Minerals, and the Physical Stack Behind AI

Lloyd Blankfein on Risk, Crisis, and Leadership

Marc Andreessen on Builder Culture in the Age of AI

Crypto Fund 5: We Raised $2.2B. Here’s Why.

The New Space Race: NASA, Artemis, and the Race to the Moon

Sarah Rogers: Free Speech, AI Diplomacy, and What America Owes Its Allies

Balaji and Taylor Lorenz on AI and Media

Workday’s Last Workday? AI and the Future of Enterprise Software

The Shift in Global Drug Development

John and Patrick Collison on Stripe's Growth, Agent Commerce, and the Future of Software

Ben Horowitz on Venture Capital and AI

AI Inside the Enterprise

Martin Shkreli on AI, Pharma, and What Actually Matters

Balaji Srinivasan: Prove Correct, Not Just Go Direct

Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon

The System Behind Self-Driving: Waymo’s Dmitri Dolgov

Technology, Culture, and the Next AI Interface with signüll

Replit's CEO on Vibe Coding, Wealth Building, and What Most People Get Wrong About AI

Ben Horowitz on AI Infrastructure, Economics and The New Laws of Software

Building Agents at Home: Parenting, Work, and Benevolent Neglect

What Running Windows at Microsoft Taught Steven Sinofsky About Apple

Who Controls AI Acceleration? Vitalik Buterin and Guillaume Verdon Debate

The Agent Era: Building Software Beyond Chat with Box CEO Aaron Levie

Balaji on Why AI Raises the Cost of Verification

Peter Yang on Small Teams, Coding Agents, and Why Human Ambition Has No Ceiling

Marc Andreessen on AI Winters and Agent Breakthroughs

Alex Blania on Proof of Human and Building World's Identity Network

What Happens When a Public Company Goes All In on AI

How Radiant and Heron Are Rethinking Power Generation and Delivery

Marc Andreessen on Evaluating Founders and AI's Consumer Surplus

The SpaceX and Tesla Playbook for Hard Tech Startups

Security, Resilience, and the Future of Mobile Infrastructure

Submarines and the Future of Defense Manufacturing

The Missing Power Layer of Modern Warfare

Why Every Satellite Needs Earth | Northwood CEO on a16z

Inside Palantir: Building Software That Matters with Shyam Sankar

AI Just Gave You Superpowers — Now What?

What's Missing Between LLMs and AGI - Vishal Misra & Martin Casado

AI Startups vs. Big Chatbots — With Olivia Moore

Marc Andreessen on the Mindset of Great Founders — with David Senra

Emil Michael: Iran, Anthropic and the Future of AI at the Pentagon

Palantir CEO Alex Karp on the Zero-Sum AI Race

What It Takes to Clear a Million Crimes a Year with Flock Safety's CEO

The Top 100 Gen AI Consumer Apps

Andrew Huberman: Peptides, Sleep Tech, and the End of Obesity

Atlassian CEO on the SaaS Apocalypse, AI Agents & What Comes Next

Ben Thompson: Anthropic, the Pentagon, and the Limits of Private Power

Deploying AI in Healthcare

Ben Horowitz On What Makes a Great Founder

Chris Dixon: From Quant Trading to Building a16z Crypto

a16z's New Media Playbook

When Giants Don’t Go Public: Inside the $5 Trillion Private Tech Market

Ben Horowitz: RSI, Crypto as AI Money, & Classified Physics

Patrick Collison on Stripe’s Early Choices, Smalltalk, and What Comes After Coding