How AI Learns to Smell with Alex Wiltschko - #771
Episode
59 min
Read time
2 min
Topics
Investing, Startups, Fundraising & VC
AI-Generated Summary
Key Takeaways
- ✓Principal Odor Map: The olfactory embedding space requires approximately 300 dimensions to model smell accurately — matching the 300+ receptor channel count in the human nose. Training a graph neural network on molecule-to-odor pairs produces a structured map where perceptually similar scents cluster as geographic neighbors, enabling arithmetic-style manipulation of fragrance properties.
- ✓Odor Turing Test benchmark: To validate predictive accuracy, Osmo predicted the smell of never-before-synthesized molecules, sealed those predictions, then had trained human panelists evaluate the physical samples blind. The model matched or exceeded any single panelist's accuracy, establishing a concrete, reproducible benchmark for olfactory AI performance evaluation.
- ✓Data moat over model architecture: Osmo's 5.43-million-scent dataset — built entirely in-house because no external labeling vendor exists for smell — outpaces century-old fragrance companies whose legacy data sits in disconnected spreadsheets. Prioritizing data collection infrastructure over algorithmic novelty produces compounding advantages as every new customer formulation generates additional training signal.
- ✓Fleet-of-models architecture: Olfactory intelligence at Osmo runs as dozens of specialized models — covering perceptual prediction, regulatory safety, manufacturability, and consumer preference — rather than one unified foundation model. Regulatory requirements mandate discrete safety outputs, making multi-head or fully unified architectures impractical; the fleet connects along a shared embedding spine similar to autonomous vehicle stacks.
- ✓Fragrance industry as funding mechanism: Osmo operates a factory robot capable of producing a new fragrance formula every 100 seconds. Customers submit text, image, or audio descriptions; models convert those inputs into formulas blended from pre-approved ingredients. Each commercial order funds further data collection, creating a self-sustaining loop between revenue generation and olfactory foundation model development.
What It Covers
Alex Wiltschko, founder of Osmo and former Google DeepMind researcher, explains how his team built olfactory AI by solving the century-old structure-odor mapping problem, creating a 5.43-million-scent dataset, and deploying fragrance-design models that now generate commercially viable products for real customers.
Key Questions Answered
- •Principal Odor Map: The olfactory embedding space requires approximately 300 dimensions to model smell accurately — matching the 300+ receptor channel count in the human nose. Training a graph neural network on molecule-to-odor pairs produces a structured map where perceptually similar scents cluster as geographic neighbors, enabling arithmetic-style manipulation of fragrance properties.
- •Odor Turing Test benchmark: To validate predictive accuracy, Osmo predicted the smell of never-before-synthesized molecules, sealed those predictions, then had trained human panelists evaluate the physical samples blind. The model matched or exceeded any single panelist's accuracy, establishing a concrete, reproducible benchmark for olfactory AI performance evaluation.
- •Data moat over model architecture: Osmo's 5.43-million-scent dataset — built entirely in-house because no external labeling vendor exists for smell — outpaces century-old fragrance companies whose legacy data sits in disconnected spreadsheets. Prioritizing data collection infrastructure over algorithmic novelty produces compounding advantages as every new customer formulation generates additional training signal.
- •Fleet-of-models architecture: Olfactory intelligence at Osmo runs as dozens of specialized models — covering perceptual prediction, regulatory safety, manufacturability, and consumer preference — rather than one unified foundation model. Regulatory requirements mandate discrete safety outputs, making multi-head or fully unified architectures impractical; the fleet connects along a shared embedding spine similar to autonomous vehicle stacks.
- •Fragrance industry as funding mechanism: Osmo operates a factory robot capable of producing a new fragrance formula every 100 seconds. Customers submit text, image, or audio descriptions; models convert those inputs into formulas blended from pre-approved ingredients. Each commercial order funds further data collection, creating a self-sustaining loop between revenue generation and olfactory foundation model development.
Notable Moment
Wiltschko points out that 99% of Earth's species — bacteria, fungi, plants, insects — communicate exclusively through chemistry, never language or images. Current foundation models trained only on human-generated text and visuals therefore miss the vast majority of planetary intelligence, which exists entirely as molecular signals.
Episode Transcript
AI has advanced primarily by learning from the digital world, text, images, audio, and increasingly video. But many of the problems people want AI to solve live outside these modalities in the physical world. Smell is one of the most interesting examples. It's how animals detect disease, identify food, navigate environments, and communicate through chemistry. Yet, scent has remained largely outside the reach of computing because, unlike language or images, there has never been a practical way to digitize it at scale. Alex Wolchko, founder and CEO of Osmo and a formal Google DeepMind researcher, is working to change this. His team is building what they call olfactory intelligence, AI systems that can model, predict, and design scents while creating the datasets and infrastructure needed to bring smell to the digital world. In this conversation, we explore what it takes to give computers a sense of smell, why scent is such a difficult AI problem, and what it teaches us about the next generation of foundation models. Here's Alex. 99% of species on this planet can only speak with chemistry. Right? Thinking of bacteria and fungi and and plants and insects. Like, they just only can talk with molecules. And I think that it's really worth adding other kind of alien forms of intelligence to our AI models. And the way to do that is to train it on the intellectual output of those other intellects, which is that's chemistry. That's the sense that's in the air. They're produced by living things for reasons to talk to each other. I'm Sam Charrington, and this is the Twimble AI podcast. For over a decade, I've been exploring the ideas and innovation shaping the future of AI through conversations like this one that help you understand what's real, what's next, and what matters. Let's jump in. When I think about giving computers a sense of smell, there's kind of two angles to this. One is, you know, there's some scent out in the world, and I want my computer to be able to recognize it the same way I do. And the other, which is, I think, more along the lines of what you're working on at Osmo, at least initially, is to have the computer kind of grok the idea of scent so that it can create new ones. Any scent that's been given to computers, there's three kind of broad steps. You gotta read the world to, like, turn atoms into bits and information. You have to map it, like, understand it. So, you know, be able to manipulate it digitally, encode it, send it, and that's like JPEG and RGB. Right? And then you have to be able to write it back out again. Right? So, printer or a display or a speaker. And so the thing we focused on at Google Brain was the missing piece, which is for scent is the map. So color has had a map for representation of well, what to what thing? Exactly. …
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“Alex Wiltschko, founder of Osmo and former Google DeepMind researcher, explains how his team built olfactory AI by solving the century-old structure-odor mapping problem, creating a 5.43-million-scent dataset, and deploying fragrance-design models.”
“Alex Wiltschko, founder of Osmo and former Google DeepMind researcher”
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