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a16z Podcast

Inferact: Building the Infrastructure That Runs Modern AI

43 min episode · 2 min read
·
Simon Moe,Woosuk Kwon

Episode

43 min

Read time

2 min

Topics

Startups, Leadership, Design & UX

AI-Generated Summary

Key Takeaways

  • Page Attention Architecture: VLLM solves the fundamental problem that language model requests vary dramatically in size—from single-word prompts to hundred-page documents—requiring dynamic batching and memory management instead of traditional static tensor operations. The system processes one token across all concurrent requests per step, handling nondeterministic output lengths where models decide their own stopping points rather than following predetermined patterns like image classification workloads.
  • Open Source Scaling Model: VLLM operates with 50+ full-time contributors and 2,000+ total contributors across GitHub, supported by model providers (Mistral, Hugging Face), hardware vendors (NVIDIA, AMD, Google, Intel), and infrastructure companies. This solves the M-times-N problem where each participant contributes to one universal layer instead of building separate integrations, with continuous integration costs exceeding one million dollars annually to test every commit across deployment scenarios.
  • Agentic Workload Complexity: Agent-based AI systems fundamentally disrupt cache management because conversations extend to hundreds or thousands of turns with external tool interactions (sandbox execution, web searches, Python scripts) creating unpredictable wait times from one second to hours. Traditional cache eviction patterns fail when the system cannot determine if an agent has finished thinking or is waiting for external environment responses, requiring co-optimization of agent architecture with inference infrastructure.
  • Hardware-Model Co-Design: Model architecture must be specialized for specific compute targets—designs optimized for NVIDIA H100 chips differ drastically from B200 or GB200 NVL72 systems, and differ again for TPUs. Vertical stack integration across data, model architecture, and hardware creates performance advantages that closed-source providers cannot deliver for diverse enterprise use cases requiring different context lengths, reasoning capabilities, and deployment environments across heterogeneous infrastructure.
  • Deployment at Consumer Scale: Amazon deploys VLLM to power the Rufus shopping assistant, processing every search query and bot interaction on their front-page feature. Character AI deployed experimental speculative decoding features to hundreds of GPUs before the code merged into the main branch, demonstrating how production deployments adopt cutting-edge optimizations within days of initial implementation, requiring PhD-level reliability standards for code affecting millions of consumer transactions.

What It Covers

Simon Moe and Woosuk Kwon, cofounders of Infraact and creators of VLLM, explain how AI inference has evolved from a simple side project in 2022 to one of computing's most complex challenges, requiring sophisticated memory management, dynamic request scheduling, and support for 400,000-500,000 GPUs running diverse models across heterogeneous hardware architectures worldwide.

Key Questions Answered

  • Page Attention Architecture: VLLM solves the fundamental problem that language model requests vary dramatically in size—from single-word prompts to hundred-page documents—requiring dynamic batching and memory management instead of traditional static tensor operations. The system processes one token across all concurrent requests per step, handling nondeterministic output lengths where models decide their own stopping points rather than following predetermined patterns like image classification workloads.
  • Open Source Scaling Model: VLLM operates with 50+ full-time contributors and 2,000+ total contributors across GitHub, supported by model providers (Mistral, Hugging Face), hardware vendors (NVIDIA, AMD, Google, Intel), and infrastructure companies. This solves the M-times-N problem where each participant contributes to one universal layer instead of building separate integrations, with continuous integration costs exceeding one million dollars annually to test every commit across deployment scenarios.
  • Agentic Workload Complexity: Agent-based AI systems fundamentally disrupt cache management because conversations extend to hundreds or thousands of turns with external tool interactions (sandbox execution, web searches, Python scripts) creating unpredictable wait times from one second to hours. Traditional cache eviction patterns fail when the system cannot determine if an agent has finished thinking or is waiting for external environment responses, requiring co-optimization of agent architecture with inference infrastructure.
  • Hardware-Model Co-Design: Model architecture must be specialized for specific compute targets—designs optimized for NVIDIA H100 chips differ drastically from B200 or GB200 NVL72 systems, and differ again for TPUs. Vertical stack integration across data, model architecture, and hardware creates performance advantages that closed-source providers cannot deliver for diverse enterprise use cases requiring different context lengths, reasoning capabilities, and deployment environments across heterogeneous infrastructure.
  • Deployment at Consumer Scale: Amazon deploys VLLM to power the Rufus shopping assistant, processing every search query and bot interaction on their front-page feature. Character AI deployed experimental speculative decoding features to hundreds of GPUs before the code merged into the main branch, demonstrating how production deployments adopt cutting-edge optimizations within days of initial implementation, requiring PhD-level reliability standards for code affecting millions of consumer transactions.

Notable Moment

The first VLLM meetup in August 2023 drew such unexpectedly massive attendance that Andreessen Horowitz's security team called to warn the event exceeded safe capacity limits. Registration far surpassed the anticipated 10-20 people, demonstrating intense demand from systems engineers for inference optimization knowledge—a narrow, sophisticated audience not typically known for attending in-person gatherings.

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Episode Transcript

Our goal is to make VOM the world's inference engine, really push the capabilities on the open source front, and then build a universal inference layer. That means we'll have the run time to power any new model on new hardware for new application, be able to tailor that to extreme efficiency and support all the AI workflow going forward. I fundamentally believe that open source, especially how VRM itself is structured, is critical to the AI infrastructure in the world. And what we want to do with this infract is to support, maintain, steward, and push forward the open source ecosystem. It is only that VOM, when VOM becomes a standard and VOM help everybody to achieve what they need to do, then our company in the sense have the right meaning and to be able to support everybody around it. What if the hardest problem in artificial intelligence isn't training smarter models, but simply keeping them running? For most of the history of computing, once a system was built, the hard part was over. You wrote the program, pressed run, and the machine behaved predictably. Even early machine learning followed that pattern. Inputs were standardized, workloads were regular, the computer did its job and stopped. Large language models quietly broke that assumption. Every request is different. Prompts could be a sentence or an entire archive. Outputs can end instantly or stretch on indefinitely. Thousands of users can arrive at once, each making incompatible demands on the same hardware. And all of this has to happen in real time on GPUs that were never designed for this kind of unpredictability. Over the last few years, this problem has moved from obscure to essential. As models have grown larger, more diverse, and more deeply embedded into products, the challenge of running AI systems has started to rival the challenge of building them. That's where the tension lies. A public story of AI progress is about better models and bigger breakthroughs. But underneath it is a quieter systems problem. How do you schedule chaotic requests efficiently? How do you manage memory when you don't know when a conversation is actually finished? And what changes when AI systems stop behaving like single turn tools and start acting like agents that think, pause, and interact with the world over time. This episode focuses on the hidden layer. We examine why inference, the act of running trained AI models, has become one of the most complex and important problems in modern computing and why open source infrastructure is increasingly central to solving it. Matt Bornstein, general partner at Andreessen Horowitz, is joined by Simon Moe and Woosah Kwon, cofounders of InfraAct and creators of the open source inference engine VLLM. This is a conversation about the infrastructure beneath AI and why it may matter more than the models themselves. Infraact, a new of Infraact, a new AI inference company. Super excited to have you guys on the show today. Thank you. Thank you so …

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Books, tools, and gear mentioned in this episode

SignalCast may earn commission on purchases via these links. As an Amazon Associate, SignalCast earns from qualifying purchases.

Tools

  • vLLMBy guest
    Simon Moe and Woosuk Kwon, cofounders of Infraact and creators of VLLM, explain how AI inference has evolved from a simple side project in 2022 to one of computing's most complex challenges

Gear

  • by Google

    and differ again for TPUs
  • by NVIDIA

    Model architecture must be specialized for specific compute targets—designs optimized for NVIDIA H100 chips differ drastically from B200 or GB200 NVL72 systems
  • by NVIDIA

    designs optimized for NVIDIA H100 chips differ drastically from B200 or GB200 NVL72 systems
  • by NVIDIA

    designs optimized for NVIDIA H100 chips differ drastically from B200 or GB200 NVL72 systems

Products

  • by Amazon

    Amazon deploys VLLM to power the Rufus shopping assistant, processing every search query and bot interaction on their front-page feature
  • Character AI deployed experimental speculative decoding features to hundreds of GPUs before the code merged into the main branch

company

  • supported by model providers (Mistral, Hugging Face), hardware vendors (NVIDIA, AMD, Google, Intel)
  • supported by model providers (Mistral, Hugging Face), hardware vendors (NVIDIA, AMD, Google, Intel)
  • supported by model providers (Mistral, Hugging Face), hardware vendors (NVIDIA, AMD, Google, Intel)
  • InfraactBy guest
    Simon Moe and Woosuk Kwon, cofounders of Infraact and creators of VLLM
  • supported by model providers (Mistral, Hugging Face), hardware vendors (NVIDIA, AMD, Google, Intel)
  • supported by model providers (Mistral, Hugging Face), hardware vendors (NVIDIA, AMD, Google, Intel)
  • supported by model providers (Mistral, Hugging Face), hardware vendors (NVIDIA, AMD, Google, Intel)

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