Mark Cuban on High Drug Prices, Taxing Billionaires, and 2028
Episode
75 min
Read time
3 min
Topics
Health & Wellness, Investing, Startups
AI-Generated Summary
Key Takeaways
- ✓PBM Formulary Control: Pharmacy Benefit Managers threaten brand-name drug manufacturers with formulary removal — potentially costing them hundreds of millions across their entire drug portfolio — if those manufacturers sell through Cost Plus Drugs. This single leverage mechanism blocks transparent pricing from reaching patients. Eliminating PBMs' ability to control formularies would immediately destabilize their pricing power and force market-rate competition across the entire prescription drug supply chain.
- ✓AI Contract Auditing for Health Care Savings: Any self-insured company covering 1,000-plus employees can run their full PBM and health insurance contracts through Claude or ChatGPT with the prompt asking where pricing definitions are mismatched or fees are hidden. Cuban reports one company discovered millions in overcharges and received a refund after an audit. Self-insured employers cover 67% of workers with employer-sponsored insurance, making this the highest-leverage cost-reduction move available to corporate leadership today.
- ✓Biosimilar Price Collapse: The arrival of biosimilars — injectable drug generics — drove the largest year-over-year prescription drug price drop in over 60 years. Stelara dropped from $128,000 annually to $365 per two-month supply on Cost Plus Drugs. Humira fell from $8,000 monthly to roughly $450. Patients on high-cost injectable biologics should check costplusdrugs.com immediately, as biosimilar availability is expanding and prices continue declining as volume increases.
- ✓California Billionaire Tax Structural Flaw: The proposed 5% one-time California billionaire tax assumes liquid assets that typically don't exist — a founder owning 10% of a $10 billion private company is legally a billionaire but likely holds near-zero cash. The state's proposed solution — loaning founders money against illiquid shares so they can pay the tax back — creates circular debt with no economic benefit. Cuban argues an alternative minimum tax at the federal level would be structurally sounder and harder to evade through relocation.
- ✓Chips as the Next Speculative Asset Class: Cuban argues Nvidia and AMD chips function like rentable apartments — highest value when new, depreciating over time, generating revenue while operational. He proposes tokenizing individual chips via crypto infrastructure, selling fractional revenue rights similar to commodity contracts, creating a narrative-driven asset class that appeals to crypto capital seeking the next speculative vehicle. Bitcoin, by contrast, has failed its original thesis as a hedge against fiat instability and geopolitical risk despite ideal macro conditions.
What It Covers
Mark Cuban joins Kara Swisher on Pivot to break down why U.S. prescription drug prices remain artificially high, how PBMs manipulate formularies to block competitors like Cost Plus Drugs, why California's proposed billionaire tax is structurally flawed, and what chips-as-an-asset-class means for crypto-adjacent investors watching the next speculative narrative form.
Key Questions Answered
- •PBM Formulary Control: Pharmacy Benefit Managers threaten brand-name drug manufacturers with formulary removal — potentially costing them hundreds of millions across their entire drug portfolio — if those manufacturers sell through Cost Plus Drugs. This single leverage mechanism blocks transparent pricing from reaching patients. Eliminating PBMs' ability to control formularies would immediately destabilize their pricing power and force market-rate competition across the entire prescription drug supply chain.
- •AI Contract Auditing for Health Care Savings: Any self-insured company covering 1,000-plus employees can run their full PBM and health insurance contracts through Claude or ChatGPT with the prompt asking where pricing definitions are mismatched or fees are hidden. Cuban reports one company discovered millions in overcharges and received a refund after an audit. Self-insured employers cover 67% of workers with employer-sponsored insurance, making this the highest-leverage cost-reduction move available to corporate leadership today.
- •Biosimilar Price Collapse: The arrival of biosimilars — injectable drug generics — drove the largest year-over-year prescription drug price drop in over 60 years. Stelara dropped from $128,000 annually to $365 per two-month supply on Cost Plus Drugs. Humira fell from $8,000 monthly to roughly $450. Patients on high-cost injectable biologics should check costplusdrugs.com immediately, as biosimilar availability is expanding and prices continue declining as volume increases.
- •California Billionaire Tax Structural Flaw: The proposed 5% one-time California billionaire tax assumes liquid assets that typically don't exist — a founder owning 10% of a $10 billion private company is legally a billionaire but likely holds near-zero cash. The state's proposed solution — loaning founders money against illiquid shares so they can pay the tax back — creates circular debt with no economic benefit. Cuban argues an alternative minimum tax at the federal level would be structurally sounder and harder to evade through relocation.
- •Chips as the Next Speculative Asset Class: Cuban argues Nvidia and AMD chips function like rentable apartments — highest value when new, depreciating over time, generating revenue while operational. He proposes tokenizing individual chips via crypto infrastructure, selling fractional revenue rights similar to commodity contracts, creating a narrative-driven asset class that appeals to crypto capital seeking the next speculative vehicle. Bitcoin, by contrast, has failed its original thesis as a hedge against fiat instability and geopolitical risk despite ideal macro conditions.
- •Sports Team Valuation Risk Factors: NBA franchise valuations — exemplified by the Lakers' $12.5 billion deal — depend on two compounding assumptions: tech asset prices remaining high enough to borrow against for the required 15% ownership stake, and streaming rights deals continuing to reduce subscriber churn for platforms like Paramount Plus. If either collapses, valuations follow. Cuban bought the Dallas Mavericks for $285 million in 2000; the real value driver was always arena concerts, surrounding real estate development, and league-wide TV revenue splits — not winning championships.
Notable Moment
Cuban reveals that Meta knowingly allows AI-generated deepfakes of him to run pharmaceutical scam ads on Facebook, targeting elderly users with fake diabetes cures priced around $294. Despite Cuban sending Meta direct evidence, the platform accepts fine-print disclaimers as sufficient compliance — which Cuban frames as defining the organization's entire ethical culture.
Episode Transcript
I've got a text. The summer might be almost over, but a new bombshell has entered the villa. Meet the voices of Deepgram Flux TTS. I'm Drew, low key casual. I'm Alexis, an upbeat morning person. I'm Haley, always cheerful. Flux TTS has some real personalities that are ready to speak. You can interrupt, pause, and keep talking without losing the plot. Fancy a chat? Come try all the voices free through September 12 at deepgram.com slash keep talking. Terms apply. Support for the show comes from Injin. Running a small business means every dollar has to work hard. But if your team is still booking travel the old way, it's costing you more than you think. Injin is the fastest growing travel and spend platform in the country, built specifically for businesses like yours. Book a trip in as little as two and a half minutes. Earn up to 10% back on hotels. And in 2025, Injen customers save more than $300,000,000 on travel, with zero booking fees, no contracts, and no BS. More than a thousand businesses join Enjin every month. Join them and get $500 when your business signs up and starts traveling at enjin.com/box. Support for this show comes from Odoo. Running a business is hard enough, so why make it harder with a dozen different apps that don't talk to each other? Introducing Odoo. It's the only business software you'll ever need. It's an all in one fully integrated platform that makes your work easier. CRM, accounting, inventory, e commerce and more. And the best part? Odoo replaces multiple expensive platforms for a fraction of the cost. That's why over thousands of businesses have made the switch. So why not you? Try Odoo for free at odoo.com. That's odoo.com. Fortunately, usually, they say they'll eat me last. Right? You are the favorite billionaire. Yeah. One of them. Although you would be delicious, I will say. Elon would be gamey. Hi, everyone. This is Pivot from New York Magazine and the Vox Media Podcast Network. I'm Kara Swisher. And once again, it is Scott August 3. I so never get tired of that. And while Scott continues his August adventures, who the fuck knows where he is? I brought on yet another guest host to make him jealous. This is my goal. It is Mark Cuban, entrepreneur and cofounder of Cost Plus Drugs. He's here. Good to see you, Mark. Always good to be seen by you, Kara. It's always a pleasure. Yeah. Thank you. We we had a problem with my shirt. Do you have a it's it's m for Mark. It's m for Mark. Yeah. No better. Do you want me to tell you my want me to tell you my Michigan story? Please. My son goes there. You know that. And why I cannot stand cannot stand Michigan. Oh, my son loves it. But go ahead. So in any event, maybe three years ago, I had this guy pester me online. I want …
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Books, tools, and gear mentioned in this episode
SignalCast may earn commission on purchases via these links.
Tools
- Cost Plus DrugsRecommended
“how PBMs manipulate formularies to block competitors like Cost Plus Drugs... Stelara dropped from $128,000 annually to $365 per two-month supply on Cost Plus Drugs... Patients on high-cost injectable biologics should check costplusdrugs.com immediately”
- ClaudeRecommended
by Anthropic
“Any self-insured company covering 1,000-plus employees can run their full PBM and health insurance contracts through Claude or ChatGPT with the prompt asking where pricing definitions are mismatched or fees are hidden.”
- ChatGPTRecommended
by OpenAI
“Any self-insured company covering 1,000-plus employees can run their full PBM and health insurance contracts through Claude or ChatGPT with the prompt asking where pricing definitions are mismatched or fees are hidden.”
“Deepgram listed as sponsor of the episode”
“Enjin listed as sponsor of the episode”
“Odoo listed as sponsor of the episode”
“ShipStation listed as sponsor of the episode”
“CoreWeave listed as sponsor of the episode”
company
“streaming rights deals continuing to reduce subscriber churn for platforms like Paramount Plus”
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