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a16z Podcast

The Health Interventions Actually Worth Your Time | Justin Mares

26 min episode · 2 min read
·
Justin Mares

Episode

26 min

Read time

2 min

Topics

Health & Wellness, Leadership, Artificial Intelligence

AI-Generated Summary

Key Takeaways

  • ✓Circadian Rhythm Priority: Spending the first 30–60 minutes of each day outdoors — walking, taking calls, avoiding screens — measurably improves sleep quality and daytime energy. This single habit costs nothing and requires no equipment, making it one of the highest-return daily health behaviors available to anyone regardless of budget or fitness level.
  • ✓Seed Oil Elimination: Soybean oil now comprises nearly 20% of average American caloric intake, up from virtually zero in 1970, correlating with rising chronic disease rates. Replacing seed oils with fats from olives or avocados reduces linoleic acid and PUFA load, which animal studies link to lower inflammation, reduced fatty liver disease, and improved metabolic markers.
  • ✓Protein Diversity Over Volume: Most people source protein exclusively from muscle meat, missing collagen, gelatin, and glycine — amino acids critical for gut lining, skin, and joint health. Adding daily bone broth (two cups provides roughly 50 grams of protein) or a high-quality gelatin supplement addresses this gap without significantly increasing caloric intake.
  • ✓Targeted Supplementation via Blood Work: Rather than following generic supplement stacks, Mares recommends getting labs every six months, uploading results to an AI tool, and running 90–180 day supplement experiments. His personal protocol targets the MTHFR mutation (methylated B-complex), cardiovascular risk (nattokinase enzyme at effective clinical dose), and organ-nutrient deficiency (freeze-dried liver/kidney/spleen blend).
  • ✓Home Toxin Reduction: Tap water in major U.S. cities contains documented carcinogens and hormone-disrupting chemicals. Installing a reverse osmosis or high-quality countertop water filter, running HEPA air purifiers continuously, switching to non-Teflon cookware, and replacing conventional cleaners with non-toxic alternatives represent low-cost, high-leverage interventions that reduce daily toxic load substantially.

What It Covers

TruMed CEO Justin Mares outlines his personal health framework across food sourcing, supplementation, blood testing, and toxin reduction — arguing that most people over-complicate optimization. He also explains how TruMed enables Americans to spend tax-free HSA and FSA dollars on lifestyle-based disease prevention.

Key Questions Answered

  • •Circadian Rhythm Priority: Spending the first 30–60 minutes of each day outdoors — walking, taking calls, avoiding screens — measurably improves sleep quality and daytime energy. This single habit costs nothing and requires no equipment, making it one of the highest-return daily health behaviors available to anyone regardless of budget or fitness level.
  • •Seed Oil Elimination: Soybean oil now comprises nearly 20% of average American caloric intake, up from virtually zero in 1970, correlating with rising chronic disease rates. Replacing seed oils with fats from olives or avocados reduces linoleic acid and PUFA load, which animal studies link to lower inflammation, reduced fatty liver disease, and improved metabolic markers.
  • •Protein Diversity Over Volume: Most people source protein exclusively from muscle meat, missing collagen, gelatin, and glycine — amino acids critical for gut lining, skin, and joint health. Adding daily bone broth (two cups provides roughly 50 grams of protein) or a high-quality gelatin supplement addresses this gap without significantly increasing caloric intake.
  • •Targeted Supplementation via Blood Work: Rather than following generic supplement stacks, Mares recommends getting labs every six months, uploading results to an AI tool, and running 90–180 day supplement experiments. His personal protocol targets the MTHFR mutation (methylated B-complex), cardiovascular risk (nattokinase enzyme at effective clinical dose), and organ-nutrient deficiency (freeze-dried liver/kidney/spleen blend).
  • •Home Toxin Reduction: Tap water in major U.S. cities contains documented carcinogens and hormone-disrupting chemicals. Installing a reverse osmosis or high-quality countertop water filter, running HEPA air purifiers continuously, switching to non-Teflon cookware, and replacing conventional cleaners with non-toxic alternatives represent low-cost, high-leverage interventions that reduce daily toxic load substantially.

Notable Moment

Mares points out that the U.S. healthcare system spends 90% of its budget managing chronic conditions while allocating under 3% to prevention — then activates roughly $3 million in lifetime spending per type 2 diabetes patient, despite having zero financial incentive to prevent the diagnosis in the first place.

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Episode Transcript

There's no shortage of advice about how to optimize your health. Justin Maers thinks most people would be better off focusing on a much shorter list. In this episode, a 16 z's Daisy Wolf sits down with Justin, co founder and CEO of TruMed, to unpack what he actually does for his own health. We get into food, exercise, supplements, blood testing, sleep, sauna, and which changes he thinks offer the highest return without turning health into a full time job. And we discussed the idea behind TruMed. If so much health care spending goes toward managing chronic disease, why don't we make it easier for people to spend their own health care dollars on prevention? So I'm Justin. I'm the CEO and founder of TruMed. TruMed basically makes it possible for individuals to spend tax free HSA and FSA dollars on medical interventions that are more lifestyle in nature. So things like exercise, food, supplements, sleep aids, things like that. Then so the high level is if you qualify, if you're working to treat, reverse, or prevent a specific disease, you can invest in a gym membership or an Eight Sleep or a Peloton or something like that using tax free HSA, FSA fund. I would love to just understand a day in the life of Club Jatz Day. And I wanna understand everything about how you eat, sleep, exercise, supplement. So maybe we can just start with a very typical day in the life. Let's start in the morning. We'll end with the nighttime routine. How do you wake up in the morning? Great. So first thing I would say is at a very high level, I think that a dynamic that you see often on the Internet is basically, like, every health influencer is incentivized to say, like, the craziest shit because that's what gets a lot of attention. And so people like Brian Johnson, who, bless him, I think doing amazing things, he is like almost incentivized to talk about, oh, I injected my son's stem cells into my body and, you know, did this crazy therapy with my grandpa. He does all that stuff that I think is very interesting. I'm glad people are doing it. I, like, don't do almost any of that. So, like, my routines are pretty boring or consistent, but I think that there's a couple areas that I've gone deep that I really care about, which I'll kinda talk about. So I basically think from a a normal day, like, we'll wake up, call around, like, seven, 07:30, Wake up. Go outside. I try and spend, like, the first thirty to sixty minutes of every single day outside. Often, I'll go for a walk, like, first thing and either listen to a podcast or call somebody that I just have to have to call and chat with. So I definitely will say I think that circadian rhythm and circadian biology is pretty... It's pretty under invested in or underutilized. People …

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Books, tools, and gear mentioned in this episode

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Gear

  • “Installing a reverse osmosis or high-quality countertop water filter, running HEPA air purifiers continuously, switching to non-Teflon cookware, and replacing conventional cleaners with non-toxic alternatives represent low-cost, high-leverage interventions that reduce daily toxic load substantially.”
  • “Installing a reverse osmosis or high-quality countertop water filter, running HEPA air purifiers continuously, switching to non-Teflon cookware, and replacing conventional cleaners with non-toxic alternatives represent low-cost, high-leverage interventions that reduce daily toxic load substantially.”
  • “Installing a reverse osmosis or high-quality countertop water filter, running HEPA air purifiers continuously, switching to non-Teflon cookware, and replacing conventional cleaners with non-toxic alternatives represent low-cost, high-leverage interventions that reduce daily toxic load substantially.”

Products

  • “His personal protocol targets the MTHFR mutation (methylated B-complex), cardiovascular risk (nattokinase enzyme at effective clinical dose), and organ-nutrient deficiency (freeze-dried liver/kidney/spleen blend).”
  • “His personal protocol targets the MTHFR mutation (methylated B-complex), cardiovascular risk (nattokinase enzyme at effective clinical dose), and organ-nutrient deficiency (freeze-dried liver/kidney/spleen blend).”
  • “Installing a reverse osmosis or high-quality countertop water filter, running HEPA air purifiers continuously, switching to non-Teflon cookware, and replacing conventional cleaners with non-toxic alternatives represent low-cost, high-leverage interventions that reduce daily toxic load substantially.”
  • Bone BrothRecommended
    “Adding daily bone broth (two cups provides roughly 50 grams of protein) or a high-quality gelatin supplement addresses this gap without significantly increasing caloric intake.”
  • “Adding daily bone broth (two cups provides roughly 50 grams of protein) or a high-quality gelatin supplement addresses this gap without significantly increasing caloric intake.”

company

  • TruMedBy guest
    “TruMed CEO Justin Mares outlines his personal health framework across food sourcing, supplementation, blood testing, and toxin reduction — arguing that most people over-complicate optimization. He also explains how TruMed enables Americans to spend tax-free HSA and FSA dollars on lifestyle-based disease prevention.”

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